Manufacturing Scientist, Reagent Manufacturing

Our mission at Ansa Biotechnologies is to revolutionize the way we make DNA. Compared to reading or editing life’s code, writing new code from scratch has remained one of the field’s most elusive challenges. At Ansa, we are putting nature to work, creating novel enzymatic solutions that will redefine how we build DNA. We believe that the biggest challenges our world faces will be solved using biotechnology and that DNA synthesis is the fuel for that transformation. Our enzyme-based approach (published in Nature Biotechnology) promises to dramatically accelerate innovation in biological research and biotechnology, including therapeutics, diagnostics, biomanufacturing, and synthetic biology. We look forward to our DNA products making an impact.

High-quality reagents are the foundation of Ansa’s DNA synthesis platform and downstream workflow. In this role, you will own the day-to-day production of master mixes, buffers, and chemical reagents — formulating, QC testing and release at an increasing scale. As a member of our manufacturing team, you will also be responsible for making process improvements, e.g., setting appropriate QC metrics, authoring and revising formulation, QC and raw material acceptance batch records, and mentoring other manufacturing associates. You will also support protein production by executing and scaling downstream protein purification processes from bench scale through pilot scale, including chromatographic capture and polishing, process-scale purification, and TFF-based UF/DF for concentration, buffer exchange, and final product formulation. Beyond reagent manufacturing and protein production, you will be part of a dynamic, cross-functional, highly collaborative team operating at the interface of development, supply chain and production.

If you have a passion for the life sciences and advancing new DNA synthesis technologies, this job is for you!

Responsibilities

• Formulate, aliquot, and release master mixes, buffers, and chemical reagents to standard operating procedures (SOPs) with high attention-to-detail and consistency.
• Execute and scale downstream protein purification processes from R&D through pilot scale, including chromatographic capture and polishing steps, process-scale purification, and TFF-based ultrafiltration/diafiltration (UF/DF) for concentration, buffer exchange, and final product formulation.
• Run in-process and release QC on incoming raw materials and finished goods; investigate out-of-spec results and drive them to resolution.
• Maintain careful records for sample traceability using custom LIMS and existing record-keeping systems.
• Update and maintain documentation (SOPs) and work instructions as needed. 
• Transfer new reagent formulations and protocols from R&D into a rapidly scaling manufacturing pipeline, working alongside technology transfer and development teams.
• Own inventory, material planning, and cold-chain storage for critical reagents to ensure consistent and uninterrupted supply.
• Train and mentor manufacturing associates; serve as a shift point-of-contact for troubleshooting and escalation.
• Work with teammates to design and scale next-generation manufacturing systems.
• Must be able to lift 50lbs and stand for long periods of time.
• Collaborating in a team environment: At Ansa, communication between teams is critical–our technology is built on enzymes, chemistry, and automation. Additionally, we believe that honesty and openness are an instrumental part of the scientific endeavor
  
  

Experience

• A minimum of 3 years of relevant work experience in reagent, biologics, or life-science manufacturing, including hands-on reagent formulation.
• Strong practical knowledge of protein purification (ion exchange, affinity, SEC chromatography).
• Expertise in TFF UF/DF operations (flat cassette formats, flux optimization, concentration, and diafiltration).
• Demonstrated experience formulating critical reagents and buffers according to formulation batch records and QC release procedures, including documentation in a controlled system (LIMS, ERP, QMS).
• Demonstrated experience working within the context of a quality management system, e.g., CAPA, non-conformance, status control and traceability.
• Demonstrated ability to plan and scale quickly to meet reagent demand.
• Experience working with supply chain to ensure adequate inventory of raw materials.
• Proven track-record of operating laboratory equipment following SOPs and directions for both simple and highly complex processes.
• Ability to learn and adapt quickly in a multidisciplinary environment with tight deadlines and specifications.
• Excellent interpersonal and communication skills with the ability to clearly discuss and present technical concepts and results.
• Commitment to demonstrating kindness, respect, and collaboration with a diverse set of colleagues of different backgrounds and disciplines. 
• Availability to work a Monday–Friday day shift on-site in Emeryville, CA.

What We Offer: 

• Competitive hourly pay and equity, with a consistent Monday–Friday day-shift schedule. 
• Generous benefits package including health, dental, and vision
• Ongoing professional development and training opportunities
• A collaborative and innovative work environment
• The opportunity to be part of a company at the forefront of synthetic biology and innovation
• San Francisco Bay Area Pay Range - $42-$47/hr

Ansa Biotechnologies is an Equal Opportunity Employer

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation,
gender identity or expression, national origin, age, disability, veteran status, or any other
characteristic protected by applicable law.

At Ansa, we are building a high-performing team focused on changing how scientists access
DNA. We look for people who are curious, rigorous, accountable, and excited to work on hard
problems. Our hiring decisions are based on merit, qualifications, experience, and the needs of
the business.